Personal information

• First Name: Jurre
• Last Name: Hageman
• Place of Birth: Gouda
• Date of Birth: 23-01-1978
• E-mail: jurrehageman@gmail.com
• LinkedIn
• Github (personal)
• Github (work)
• Google Scholar

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Work experience

• 2016-currently: Hanzehogeschool Groningen Institute for Life Science en Technology

  I am a Senior lecturer of the Biology and Medical Laboratory education program involved in curriculum development. My task is to keep track of the future of the Biological and Medical Research major and to implement new content-related and educational concepts.

• 2009-2016: Hanzehogeschool Groningen Institute for Life Science en Technology

  I worked as a lecturer of various Molecular Biology, Biochemistry, Genetics and Bio-informatics related modules.

• 2008-2010: University Medical Center Groningen Center for Liver, Digestive and Metabolic Diseases Laboratory Pediatrics

  I worked as a Postdocteral researcher and investigated the use of nuclear receptors as targets for anti-atherosclerotic therapies in mice. I also generated various pseudo-viral vectors (Adenovirus and adeno-associated viruses) for gene manipulation.

• 2004-2008: University of Groningen Department of Radiation and Stress Cell Biology

  I worked as a PhD student on the subject of molecular chaperones and the relation with diseases where proteotoxic stress plays a major role (such as Huntington's Disease). Used various Molecular Biology, Cell Biology and cellular imaging techniques. Thesis: The human HSP70/HSP40 chaperone family, A study on its capacity to combat proteotoxic stress.

• 2001-2004: University of Groningen Department of Radiation and Stress Cell Biology

  I worked as a Research Technician on the subject of radiation-induced fibrosis and molecular chaperones. Used various Molecular Biology and Cell Biology techniques.

• 2000-2000: Centocor B.V. Leiden Quality Control Microbiology

  Worked as a quality control technician under GLP/GMP conditions.

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Education

• 2004-2008: PhD University of Groningen See working experience for details.
• 1998-2001: HLO (Reseach Technician, specialization Biotechnology) Hanzehogeschool, University of Applied Science, Groningen.
• 1994-1998: MLO (Reseach Technician, specialization Medical Microbiology) ROC Zadkine College, Rotterdam

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Internships

• 2000-2001: University of Groningen Eukaryotic Microbiology

  During this internship, I performed genetic screens to isolate novel genes involved in peroxisome degradation.

• 1997-1998: Academisch Ziekenhuis Rotterdam Department of Bacteriology

  I worked on the epidemiological typing of multi-resistant Klebsiella pneumoniae strains originating from an intensive care unit.

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Software

I am a computer enthousiast. I like programming in Python (using the Anaconda suite) and R (Tidyverse). I use Markdown and Latex for scientific writing. Furthermore, I use Linux, Git and various Bio-informatics software programs (such as Benchling, Clustal Omega and various databases such as EMBL, NCBI, Ensembl).

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Courses

• 2014: Basis Kwalificatie Examinering (BKE)
• 2013: Informatics 2 (Python course)
• 2012: Informatics 1 (Python course)
• 2012: Pedagogisch Didactische Bekwaamheid (PDB)
• 2011: Bedrijfshulpverlener (yearly updated)
• 2009: Proefdierkunde (art. 9)
• 2006: Good Laboratory Practice / Good Clinical Practice
• 2005: Project Management for Scientific Research
• 2005: Publishing in English
• 2000: Elektronenmicroscopie
• 1999: Veilige Microbiologische Technieken

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Commissions

• 2014-2015: Assessor Basis Kwalificatie Examinering
• 2013-2015: Toetscommissie

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Hobbies

Weightlifting, music, fishing, nature, traveling, programming, science.

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Conferences

• 2008: CSHL meeting on Molecular Sress Responses and Chaperones, Cold Spring Harbor, New York, USA. Newly identified molecular chaperones with high activity in the suppression of polyglutamine aggregation.
• 2007: Protein Folding & Chaperones in Biology, Tomar, Portugal. Comparison of intra-organellar chaperone capacity for dealing with stress-induced protein unfolding.
• 2007: 10th Dutch Endo Neuro Meeting, Doorwerth, Nederland. A novel Hsp40 family member is a strong suppressor of polyglutamine aggregation.
• 2003: 12th international congress of radiation research (ICRR), Brisbane, Australia. Normal tissue response to Radiation: Molecular changes in relation to tissue dysfunction. The role of TGF-beta in radiation-induced fibrosis.
• 2003: 2nd ESTRO Workshop on biology in radiation oncology, Berg en dal/Nijmegen, Nederland. Normal tissue effects: mechanisms. Activation of profibrogenic genes by radiation and TGF-beta.

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Prizes

• 2003: Klaas Breur Travel Fund. Nederlandse vereniging voor Radiobiologie.

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Patents

• 2008: co-owner of patent 17106188.1-2123. Means and methods for counteracting protein aggregation.

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Grants

• 2022: NWA CureQ (Co-applicant): Predict, Delay & Cure polyglutamine(Q) caused neurodegeneration
• 2019: SiA KIEM-VANG: Development of a fractionation and characterization strategy to identify antimicrobial anthocyanin molecules for application as novel plant-based antibiotics
• 2018: SiA KIEM-VANG: Anthocyanins from agricultural waste: a source of next-generation antimicrobials?

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Publications

• Hageman J, Krikken AM. Single-Step Gene Knockout of the SUC2 Gene in Saccharomyces cerevisiae : A Laboratory Exercise for Undergraduate Students. J Microbiol Biol Educ. 2018 Oct 31;19(3).
• Boesjes M, Bloks VW, Hageman J, Bos T, van Dijk TH, Havinga R, Wolters H, Jonker JW, Kuipers F, Groen AK. Hepatic farnesoid X-receptor isoforms α2 and α4 differentially modulate bile salt and lipoprotein metabolism in mice. PLoS One. 2014 Dec 15.
• Heldens L, van Genesen ST, Hanssen LL, Hageman J, Kampinga HH, Lubsen NH. Protein refolding in peroxisomes is dependent upon an HSF1-regulated function. Cell Stress Chaperones. 2012 Apr 5.
• Out C, Hageman J, Bloks VW, Gerrits H, Sollewijn Gelpke MD, Bos T, Havinga R, Smit MJ, Kuipers F, Groen AK. Liver receptor homolog-1 is critical for adequate up-regulation of Cyp7a1 gene transcription and bile salt synthesis during bile salt sequestration. Hepatology. 2011 Jun;53(6):2075-85.
• Hageman J, van Waarde MA, Zylicz A, Walerych D, Kampinga HH. The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities. Biochem J. 2011 Apr 1;435(1):127-42.
• van Dijk KW, Kypreos KE, Fallaux FJ, Hageman J. Adenovirus-mediated gene transfer. Methods Mol Biol. 2011;693:321-43.
• Hageman J, Herrema H, Groen AK, Kuipers F. A role of the bile salt receptor FXR in atherosclerosis. Arterioscler Thromb Vasc Biol. 2010 Aug;30(8):1519-28.
• Hageman J, Rujano MA, van Waarde MA, Kakkar V, Dirks RP, Govorukhina N, Oosterveld-Hut HM, Lubsen NH, Kampinga HH. A DNAJB chaperone subfamily with HDAC-dependent activities suppresses toxic protein aggregation. Mol Cell. 2010 Feb 12;37(3).
• Hageman J, Kampinga HH. Computational analysis of the human HSPH/HSPA/DNAJ family and cloning of a human HSPH/HSPA/DNAJ expression library. Cell Stress Chaperones. 2009 Jan;14(1):1-21.
• Kampinga HH, Hageman J, Vos MJ, Kubota H, Tanguay RM, Bruford EA, Cheetham ME, Chen B, Hightower LE. Guidelines for the nomenclature of the human heat shock proteins. Cell Stress Chaperones. 2009 Jan;14(1):105-11.
• Vos MJ, Hageman J, Carra S, Kampinga HH. Structural and functional diversities between members of the human HSPB, HSPH, HSPA, and DNAJ chaperone families. Biochemistry. 2008 Jul 8;47(27):7001-11.
• Hageman J, Vos MJ, van Waarde MA, Kampinga HH. Comparison of intra-organellar chaperone capacity for dealing with stress-induced protein unfolding. J Biol Chem. 2007 Nov 23;282(47):34334-45.
• Hageman J, Eggen BJ, Rozema T, Damman K, Kampinga HH, Coppes RP. Radiation and transforming growth factor-beta cooperate in transcriptional activation of the profibrotic plasminogen activator inhibitor-1 gene. Clin Cancer Res. 2005 Aug 15.
• Goessens WH, Lemmens-den Toom N, Hageman J, Hermans PW, Sluijter M, de Groot R, Verbrugh HA. Evaluation of the Vitek 2 system for susceptibility testing of Streptococcus pneumoniae isolates. Eur J Clin Microbiol Infect Dis. 2000 Aug;19(8):618-2.

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